We and others have shown that inhibition of this pathway with specific small molecule MAPK/extracellular signal-regulated kinase kinase (MEK) inhibitors induces a wide range of apoptotic responsiveness in human melanoma cells both in vitro and in vivo. ![]() Mutually exclusive activating mutations in NRAS or BRAF have been identified in ∼85% of melanomas, and components of this pathway have been developed as molecular targets for therapeutic intervention. Constitutive activation of the mitogen-activated protein kinase (MAPK) pathway is implicated in the development and progression of many human cancers, including melanoma.
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